The George C. Marshall Space Flight Center (MSFC), located in Redstone Arsenal, Alabama (Huntsville postal address), is the U.S. government's civilian rocketry and spacecraft propulsion research center. As the largest NASA center, MSFC's first mission was developing the Saturn launch vehicles for the Apollo program. Marshall has been the lead center for the Space Shuttle main propulsion and external tank; payloads and related crew training; International Space Station (ISS) design and assembly; computers, networks, and information management; and the Space Launch System (SLS). Located on the Redstone Arsenal near Huntsville, MSFC is named in honor of General of the Army George C. Marshall.

The center contains the Huntsville Operations Support Center (HOSC), also known as the International Space Station Payload Operations Center. This facility supports ISS launch, payload, and experiment activities at the Kennedy Space Center. The HOSC also monitors rocket launches from Cape Canaveral Space Force Station when a Marshall Center payload is on board.